Longevity Science

Nicotinamide adenine dinucleotide (NAD+) is a molecule essential to cellular energy metabolism and is actively studied for its role in processes associated with aging and cellular function. Scientific literature has explored how NAD+ levels relate to DNA repair, mitochondrial activity, and metabolic pathways involved in overall cellular health.

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Featured Articles

NAD and the aging process: Role in life, death and everything in between

NAD+ metabolism and its roles in cellular processes during aging

NAD+ metabolism and the control of energy homeostasis - a balancing act between mitochondria and the nucleus

Nicotinamide Riboside - The Current State of Research and Therapeutic Uses

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

Increased demand for NAD+ relative to ATP drives aerobic glycolysis

NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1α pathway

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

NAD+ Metabolism in Cardiac Health, Aging, and Disease

NAD+ homeostasis in human health and disease

Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes

Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes

Interacting NAD+ and Cell Senescence Pathways Complicate Anti-aging Therapies

The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline

Senescent cells promote tissue NAD+ decline during aging via the activation of the CD38+ macrophages