NAD+ promotes longevity through multiple mechanisms including DNA repair. Restoration of NAD+ has been shown to increase lifespan in mice by the human equivalent of 4 years.
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Featured Articles
NAD and the aging process: Role in life, death and everything in between
NAD+ metabolism and its roles in cellular processes during aging
NAD+ metabolism and the control of energy homeostasis - a balancing act between mitochondria and the nucleus
Nicotinamide Riboside - The Current State of Research and Therapeutic Uses
NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice
Increased demand for NAD+ relative to ATP drives aerobic glycolysis
NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1α pathway
Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence
NAD+ Metabolism in Cardiac Health, Aging, and Disease
NAD+ homeostasis in human health and disease
Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes
Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes
Interacting NAD+ and Cell Senescence Pathways Complicate Anti-aging Therapies
The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline
Senescent cells promote tissue NAD+ decline during aging via the activation of the CD38+ macrophages